Lapatinib (GW572016)

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Selleck Chemicals

S2111-25MG

€144,00 EUR
€144,00 EUR
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Lapatinib (GW572016) is an inhibitor of EGFR and HER2 and related targets used in studies of PI3K-Akt-mTOR Signaling and MAPK / ERK Signaling. It is especially relevant when investigators need a named chemical input and interpretable readouts connected to growth-factor signaling, survival control, and nutrient-sensing outputs and mitogenic kinase cascades, proliferation control, and differentiation-linked signaling in cancer and cell signaling models.

By inhibiting EGFR and HER2 and related targets, Lapatinib (GW572016) can be used to examine growth-factor signaling, survival control, and nutrient-sensing outputs and mitogenic kinase cascades, proliferation control, and differentiation-linked signaling. The kinase annotation adds relevance to biochemical kinase assays, phospho-signaling studies, and selectivity profiling, together with downstream-response mapping in the same experimental setting. In cancer and cell signaling models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.

Research Applications

  • Target-focused assays involving EGFR and HER2 and related targets
  • Pathway perturbation studies connected to PI3K-Akt-mTOR Signaling and MAPK / ERK Signaling
  • Concentration-response inhibition and target-dependence studies
  • Biochemical kinase assays, phospho-signaling studies, and selectivity profiling

Overall, Lapatinib (GW572016) is appropriate when a defined chemical perturbant is needed to connect EGFR and HER2 and related targets with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in cancer and cell signaling models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.

Targets:
EGFR • HER2 • HER4
Target Class:
Kinase
Pathways:
PI3K-Akt-mTOR Signaling • MAPK / ERK Signaling
Research Area:
Cancer • Cell Signaling
CAS No.:
231277-92-2
Molecular Weight:
581.06
Formula:
C₂₉H₂₆ClFN₄O₄S
SMILES:
CS(=O)(=O)CCNCC1=CC=C(O1)C2=CC3=C(C=C2)N=CN=C3NC4=CC(=C(C=C4)OCC5=CC(=CC=C5)F)Cl
InChIKey:
BCFGMOOMADDAQU-UHFFFAOYSA-N
PubChem:
208908
Storage Temperature:
-20°C

For Research Use Only. Not intended for diagnostic or therapeutic use.
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