Linifanib (ABT-869)

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Selleck Chemicals

S1003-5MG

€117,00 EUR
€117,00 EUR
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Linifanib (ABT-869) is an inhibitor of PDGFR and VEGFR and related targets used in studies of MAPK / ERK Signaling and JAK-STAT Signaling and related signaling programs. In practice, this places the compound in experiments that measure mitogenic kinase cascades, proliferation control, and differentiation-linked signaling and cytokine-responsive transcriptional signaling and immune regulation in angiogenesis, apoptosis, and autophagy models.

By inhibiting PDGFR and VEGFR and related targets, Linifanib (ABT-869) can be used to examine mitogenic kinase cascades, proliferation control, and differentiation-linked signaling and cytokine-responsive transcriptional signaling and immune regulation. The kinase annotation adds relevance to biochemical kinase assays, phospho-signaling studies, and selectivity profiling, together with downstream-response mapping in the same experimental setting. In angiogenesis, apoptosis, and autophagy models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.

Research Applications

  • Target-focused assays involving PDGFR and VEGFR and related targets
  • Pathway perturbation studies connected to MAPK / ERK Signaling and JAK-STAT Signaling and related signaling programs
  • Concentration-response inhibition and target-dependence studies
  • Biochemical kinase assays, phospho-signaling studies, and selectivity profiling

Overall, Linifanib (ABT-869) is appropriate when a defined chemical perturbant is needed to connect PDGFR and VEGFR and related targets with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in angiogenesis, apoptosis, and autophagy models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.

Targets:
PDGFR • VEGFR • FLT3 • CSF-1R
Target Class:
Kinase
Pathways:
MAPK / ERK Signaling • JAK-STAT Signaling • Immune Signaling
Research Area:
Angiogenesis • Apoptosis • Autophagy • Cancer
CAS No.:
796967-16-3
Molecular Weight:
375.41
Formula:
C₂₁H₁₈FN₅O
SMILES:
CC1=CC(=C(C=C1)F)NC(=O)NC2=CC=C(C=C2)C3=C4C(=CC=C3)NN=C4N
InChIKey:
MPVGZUGXCQEXTM-UHFFFAOYSA-N
PubChem:
11485656
Storage Temperature:
-20°C

For Research Use Only. Not intended for diagnostic or therapeutic use.
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