Losartan Potassium (DuP 753)

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Selleck Chemicals

S1359-50MG

€144,00 EUR
€144,00 EUR
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Losartan Potassium (DuP 753) is an antagonist of Angiotensin Receptors used in studies of GPCR Signaling. In practice, this places the compound in experiments that measure receptor-driven second-messenger signaling and desensitization dynamics in cardiovascular models.

By blocking Angiotensin Receptors, Losartan Potassium (DuP 753) can be used to examine receptor-driven second-messenger signaling and desensitization dynamics. The gpcr annotation adds relevance to GPCR pharmacology, ligand-binding, and signaling assays, together with downstream-response mapping in the same experimental setting. In cardiovascular models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.

Research Applications

  • Target-focused assays involving Angiotensin Receptors
  • Pathway perturbation studies connected to GPCR Signaling
  • Receptor-blockade and ligand-competition studies
  • GPCR pharmacology, ligand-binding, and signaling assays

Overall, Losartan Potassium (DuP 753) is appropriate when a defined chemical perturbant is needed to connect Angiotensin Receptors with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in cardiovascular models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.

Targets:
Angiotensin Receptors
Target Class:
GPCR
Pathways:
GPCR Signaling
Research Area:
Cardiovascular
CAS No.:
124750-99-8
Molecular Weight:
462.01
Formula:
C₂₂H₂₃ClKN₆O
SMILES:
CCCCC1=NC(=C(N1CC2=CC=C(C=C2)C3=CC=CC=C3C4=NN=N[N-]4)CO)Cl.[K+]
Storage Temperature:
-20°C

For Research Use Only. Not intended for diagnostic or therapeutic use.
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