Madecassic acid

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Selleck Chemicals

S9502-10MG

€95,00 EUR
€95,00 EUR
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Madecassic acid is a natural-product modulator of NF-kB and TNF-alpha and related targets used in studies of JAK-STAT Signaling and NF-kB Signaling and related signaling programs. In practice, this places the compound in experiments that measure cytokine-responsive transcriptional signaling and immune regulation and inflammatory transcriptional control and stress-responsive survival signaling in immunology and inflammation models.

By modulating NF-kB and TNF-alpha and related targets, Madecassic acid can be used to examine cytokine-responsive transcriptional signaling and immune regulation and inflammatory transcriptional control and stress-responsive survival signaling. The immunomodulator annotation adds relevance to immune-cell activation, cytokine, and mediator assays, together with downstream-response mapping in the same experimental setting. In immunology and inflammation models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.

Research Applications

  • Target-focused assays involving NF-kB and TNF-alpha and related targets
  • Pathway perturbation studies connected to JAK-STAT Signaling and NF-kB Signaling and related signaling programs
  • Context-dependent response profiling and mechanism comparison
  • Immune-cell activation, cytokine, and mediator assays

Overall, Madecassic acid is appropriate when a defined chemical perturbant is needed to connect NF-kB and TNF-alpha and related targets with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in immunology and inflammation models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.

Targets:
NF-kB • TNF-alpha • Interleukins • COX-2
Target Class:
Immunomodulator
Pathways:
JAK-STAT Signaling • NF-kB Signaling • Immune Signaling
Research Area:
Immunology • Inflammation
CAS No.:
18449-41-7
Molecular Weight:
504.70
Formula:
C₃₀H₄₈O₆
SMILES:
CC1CCC2(CCC3(C(=CCC4C3(CC(C5C4(CC(C(C5(C)CO)O)O)C)O)C)C2C1C)C)C(=O)O
InChIKey:
PRAUVHZJPXOEIF-UHFFFAOYSA-N
PubChem:
9798973
Storage Temperature:
-20°C

For Research Use Only. Not intended for diagnostic or therapeutic use.
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The purchase of this product does not grant any license for commercial use, manufacturing, or clinical applications. The user is responsible for ensuring compliance with applicable laws and third-party rights.