Marizomib (Salinosporamide A)
Selleck Chemicals
SKU:S7504-1MG
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Marizomib (Salinosporamide A) is an inhibitor of Proteasome used in studies of Protein Degradation / Proteasome. It is especially relevant when investigators need a named chemical input and interpretable readouts connected to ubiquitin-dependent turnover, proteostasis, and targeted protein degradation in cancer and protein homeostasis models.
By inhibiting Proteasome, Marizomib (Salinosporamide A) can be used to examine ubiquitin-dependent turnover, proteostasis, and targeted protein degradation. The protease annotation adds relevance to protease-activity, cleavage, and substrate-processing assays, together with downstream-response mapping in the same experimental setting. In cancer and protein homeostasis models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.
Research Applications
- Target-focused assays involving Proteasome
- Pathway perturbation studies connected to Protein Degradation / Proteasome
- Concentration-response inhibition and target-dependence studies
- Protease-activity, cleavage, and substrate-processing assays
Overall, Marizomib (Salinosporamide A) is appropriate when a defined chemical perturbant is needed to connect Proteasome with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in cancer and protein homeostasis models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.
- Targets:
- Proteasome
- Target Class:
- Protease
- Pathways:
- Protein Degradation / Proteasome
- Research Area:
- Cancer • Protein Homeostasis
- CAS No.:
- 437742-34-2
- Molecular Weight:
- 313.78
- Formula:
- C₁₅H₂₀ClNO₄
- SMILES:
- CC12C(C(=O)NC1(C(=O)O2)C(C3CCCC=C3)O)CCCl
- InChIKey:
- NGWSFRIPKNWYAO-UHFFFAOYSA-N
- PubChem:
- 11347535
- Storage Temperature:
- -20°C
For Research Use Only. Not intended for diagnostic or therapeutic use.
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