Minocycline

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Selleck Chemicals

E8212

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Minocycline is an antagonist of HIF used in studies of pathway modulation. It is especially relevant in cancer, cell signaling, and infectious disease models, where defined compound exposure can be linked to pathway-dependent signal amplification or attenuation.

By blocking HIF, Minocycline can be used to examine pathway-dependent signal amplification or attenuation. This target class is commonly examined through pathway-reporter and mechanistic-phenotyping studies, together with downstream-response mapping. In cancer, cell signaling, and infectious disease models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.

Research Applications

  • Target-focused assays involving HIF
  • Receptor-blockade and ligand-competition studies
  • Pathway-reporter and mechanistic-phenotyping studies
  • Phenotypic profiling in cancer, cell signaling, and infectious disease models

Overall, Minocycline is appropriate when a defined chemical perturbant is needed to connect HIF with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in cancer, cell signaling, and infectious disease models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.

Targets:
HIF
Target Class:
Signaling Pathway Modulator
Research Area:
Cancer • Cell Signaling • Infectious Disease • Neuroscience
CAS No.:
10118-90-8
Molecular Weight:
457.48
SMILES:
CN(C)c1ccc(O)c2c1C[C@H]1C[C@H]3[C@H](N(C)C)C(O)=C(C(=N)O)C(=O)[C@@]3(O)C(O)=C1C2=O
InChIKey:
DYKFCLLONBREIL-KVUCHLLUSA-N
PubChem:
54675783
Storage Temperature:
-20°C

For Research Use Only. Not intended for diagnostic or therapeutic use.
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