MK-4101

1 1

Selleck Chemicals

S8200-2MG

€95,00 EUR
€95,00 EUR
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MK-4101 is an inhibitor of Hedgehog used in studies of Wnt Signaling and Hedgehog Signaling and related signaling programs. It is especially relevant when investigators need a named chemical input and interpretable readouts connected to beta-catenin-dependent transcription and developmental signaling and morphogen-dependent developmental signaling and transcriptional patterning in apoptosis, cancer, and developmental biology models.

By inhibiting Hedgehog, MK-4101 can be used to examine beta-catenin-dependent transcription and developmental signaling and morphogen-dependent developmental signaling and transcriptional patterning. The signaling pathway modulator annotation adds relevance to pathway-reporter and mechanistic-phenotyping studies, together with downstream-response mapping in the same experimental setting. In apoptosis, cancer, and developmental biology models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.

Research Applications

  • Target-focused assays involving Hedgehog
  • Pathway perturbation studies connected to Wnt Signaling and Hedgehog Signaling and related signaling programs
  • Concentration-response inhibition and target-dependence studies
  • Pathway-reporter and mechanistic-phenotyping studies

Overall, MK-4101 is appropriate when a defined chemical perturbant is needed to connect Hedgehog with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in apoptosis, cancer, and developmental biology models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.

Targets:
Hedgehog
Target Class:
Signaling Pathway Modulator
Pathways:
Wnt Signaling • Hedgehog Signaling • Apoptosis
Research Area:
Apoptosis • Cancer • Developmental Biology • Stem Cell Biology
CAS No.:
935273-79-3
Molecular Weight:
493.47
Formula:
C₂₄H₂₄F₅N₅O
SMILES:
CN1C(=NN=C1C23CCC(CC2)(CC3)C4=NOC(=N4)C5CC(C5)(F)F)C6=CC=CC=C6C(F)(F)F
Storage Temperature:
-20°C

For Research Use Only. Not intended for diagnostic or therapeutic use.
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