MK-8617

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Selleck Chemicals

S8443-5MG

€144,00 EUR
€144,00 EUR
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MK-8617 is a modulator of HIF used in studies of pathway modulation. In practice, this places the compound in experiments that measure pathway-dependent signal amplification or attenuation in angiogenesis, cancer, and cell signaling models. Dose-response comparison, orthogonal validation, and secondary assay follow-up can further sharpen mechanistic interpretation.

By modulating HIF, MK-8617 can be used to examine pathway-dependent signal amplification or attenuation. This target class is commonly examined through pathway-reporter and mechanistic-phenotyping studies, together with downstream-response mapping. In angiogenesis, cancer, and cell signaling models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.

Research Applications

  • Target-focused assays involving HIF
  • Context-dependent response profiling and mechanism comparison
  • Pathway-reporter and mechanistic-phenotyping studies
  • Phenotypic profiling in angiogenesis, cancer, and cell signaling models

Overall, MK-8617 is appropriate when a defined chemical perturbant is needed to connect HIF with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in angiogenesis, cancer, and cell signaling models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.

Targets:
HIF
Target Class:
Signaling Pathway Modulator
Research Area:
Angiogenesis • Cancer • Cell Signaling
CAS No.:
1187990-87-9
Molecular Weight:
443.45
Formula:
C₂₄H₂₁N₅O₄
SMILES:
COC1=CC=C(C=C1)C(C2=CC=C(C=C2)OC)NC(=O)C3=CN=C(NC3=O)C4=NN=CC=C4
Storage Temperature:
-20°C

For Research Use Only. Not intended for diagnostic or therapeutic use.
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The purchase of this product does not grant any license for commercial use, manufacturing, or clinical applications. The user is responsible for ensuring compliance with applicable laws and third-party rights.