Netarsudil (AR-13324)2HCl

1 1

Selleck Chemicals

S8226-2MG

€193,00 EUR
€193,00 EUR
Sold out
Shipping calculated at checkout.
Supplier
Size
View full details

Netarsudil (AR-13324)2HCl is an inhibitor of ROCK and ROCK2 used in studies of kinase signaling. It is especially relevant in cancer, cardiovascular, and cell cycle models, where defined compound exposure can be linked to phosphorylation signaling, target engagement, and selectivity relationships.

By inhibiting ROCK and ROCK2, Netarsudil (AR-13324)2HCl can be used to examine phosphorylation signaling, target engagement, and selectivity relationships. This target class is commonly examined through biochemical kinase assays, phospho-signaling studies, and selectivity profiling, together with downstream-response mapping. In cancer, cardiovascular, and cell cycle models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.

Research Applications

  • Target-focused assays involving ROCK and ROCK2
  • Concentration-response inhibition and target-dependence studies
  • Biochemical kinase assays, phospho-signaling studies, and selectivity profiling
  • Phenotypic profiling in cancer, cardiovascular, and cell cycle models

Overall, Netarsudil (AR-13324)2HCl is appropriate when a defined chemical perturbant is needed to connect ROCK and ROCK2 with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in cancer, cardiovascular, and cell cycle models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.

Targets:
ROCK • ROCK2
Target Class:
Kinase
Research Area:
Cancer • Cardiovascular • Cell Cycle • Cell Signaling
CAS No.:
1253952-02-1
Molecular Weight:
526.45
Formula:
C₂₈H₂₇N₃O₃·2HCl
SMILES:
CC1=CC(=C(C=C1)C(=O)OCC2=CC=C(C=C2)C(CN)C(=O)NC3=CC4=C(C=C3)C=NC=C4)C.Cl.Cl
Storage Temperature:
-20°C

For Research Use Only. Not intended for diagnostic or therapeutic use.
Products may be subject to intellectual property rights.

The purchase of this product does not grant any license for commercial use, manufacturing, or clinical applications. The user is responsible for ensuring compliance with applicable laws and third-party rights.