niclosamide ethanolamine

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Selleck Chemicals

E6051-100MG

€144,00 EUR
€144,00 EUR
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niclosamide ethanolamine is an inhibitor of STAT used in studies of PI3K-Akt-mTOR Signaling and JAK-STAT Signaling and related signaling programs. In practice, this places the compound in experiments that measure growth-factor signaling, survival control, and nutrient-sensing outputs and cytokine-responsive transcriptional signaling and immune regulation in apoptosis, autophagy, and cancer models.

By inhibiting STAT, niclosamide ethanolamine can be used to examine growth-factor signaling, survival control, and nutrient-sensing outputs and cytokine-responsive transcriptional signaling and immune regulation. The signaling pathway modulator annotation adds relevance to pathway-reporter and mechanistic-phenotyping studies, together with downstream-response mapping in the same experimental setting. In apoptosis, autophagy, and cancer models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.

Research Applications

  • Target-focused assays involving STAT
  • Pathway perturbation studies connected to PI3K-Akt-mTOR Signaling and JAK-STAT Signaling and related signaling programs
  • Concentration-response inhibition and target-dependence studies
  • Pathway-reporter and mechanistic-phenotyping studies

Overall, niclosamide ethanolamine is appropriate when a defined chemical perturbant is needed to connect STAT with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in apoptosis, autophagy, and cancer models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.

Targets:
STAT
Target Class:
Signaling Pathway Modulator
Pathways:
PI3K-Akt-mTOR Signaling • JAK-STAT Signaling • TGF-beta / Smad Signaling
Research Area:
Apoptosis • Autophagy • Cancer • Cell Signaling
CAS No.:
1420-04-8
Molecular Weight:
388.20
Formula:
C₁₃H₈Cl₂N₂O₄·C₂H₇NO
Storage Temperature:
-20°C

For Research Use Only. Not intended for diagnostic or therapeutic use.
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