Niclosamide

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Selleck Chemicals

S3030-50MG

€144,00 EUR
€144,00 EUR
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Niclosamide is an inhibitor of STAT used in studies of JAK-STAT Signaling. It is especially relevant in cancer, cell signaling, and immunology models, where defined compound exposure can be linked to cytokine-responsive transcriptional signaling and immune regulation.

By inhibiting STAT, Niclosamide can be used to examine cytokine-responsive transcriptional signaling and immune regulation. The signaling pathway modulator annotation adds relevance to pathway-reporter and mechanistic-phenotyping studies, together with downstream-response mapping in the same experimental setting. In cancer, cell signaling, and immunology models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.

Research Applications

  • Target-focused assays involving STAT
  • Pathway perturbation studies connected to JAK-STAT Signaling
  • Concentration-response inhibition and target-dependence studies
  • Pathway-reporter and mechanistic-phenotyping studies

Overall, Niclosamide is appropriate when a defined chemical perturbant is needed to connect STAT with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in cancer, cell signaling, and immunology models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.

Targets:
STAT
Target Class:
Signaling Pathway Modulator
Pathways:
JAK-STAT Signaling
Research Area:
Cancer • Cell Signaling • Immunology
CAS No.:
50-65-7
Molecular Weight:
327.12
Formula:
C₁₃H₈Cl₂N₂O₄
SMILES:
C1=CC(=C(C=C1[N+](=O)[O-])Cl)NC(=O)C2=C(C=CC(=C2)Cl)O
InChIKey:
RJMUSRYZPJIFPJ-UHFFFAOYSA-N
PubChem:
4477
Storage Temperature:
-20°C

For Research Use Only. Not intended for diagnostic or therapeutic use.
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