NMS-873

1 1

Selleck Chemicals

S7285-5MG

€144,00 EUR
€144,00 EUR
Sale Sold out
Taxes included. Shipping calculated at checkout.
Size
View full details

NMS-873 is an inhibitor of HSP90 and ATPases used in studies of Protein Degradation / Proteasome. It is especially relevant when investigators need a named chemical input and interpretable readouts connected to ubiquitin-dependent turnover, proteostasis, and targeted protein degradation in cancer, cell signaling, and protein homeostasis models.

By inhibiting HSP90 and ATPases, NMS-873 can be used to examine ubiquitin-dependent turnover, proteostasis, and targeted protein degradation. This context is compatible with degradation, proteasome, and protein-turnover assays, as well as transcriptional, biochemical, or phenotypic comparisons linked to the annotated pathway state. In cancer, cell signaling, and protein homeostasis models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.

Research Applications

  • Target-focused assays involving HSP90 and ATPases
  • Pathway perturbation studies connected to Protein Degradation / Proteasome
  • Concentration-response inhibition and target-dependence studies
  • Phenotypic profiling in cancer, cell signaling, and protein homeostasis models

Overall, NMS-873 is appropriate when a defined chemical perturbant is needed to connect HSP90 and ATPases with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in cancer, cell signaling, and protein homeostasis models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.

Targets:
HSP90 • ATPases
Target Class:
Other
Pathways:
Protein Degradation / Proteasome
Research Area:
Cancer • Cell Signaling • Protein Homeostasis
CAS No.:
1418013-75-8
Molecular Weight:
520.67
Formula:
C₂₇H₂₈N₄O₃S₂
SMILES:
CC1=C(C=CC(=C1)OCC2=NN=C(N2C3=CN=CC=C3)SC4CCCC4)C5=CC=C(C=C5)S(=O)(=O)C
Storage Temperature:
-20°C

For Research Use Only. Not intended for diagnostic or therapeutic use.
Products may be subject to intellectual property rights.

The purchase of this product does not grant any license for commercial use, manufacturing, or clinical applications. The user is responsible for ensuring compliance with applicable laws and third-party rights.