NRD167

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Selleck Chemicals

S9903-5MG

€183,00 EUR
€183,00 EUR
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NRD167 is an inhibitor of Sirtuins used in studies of DNA Damage Response and Epigenetic Regulation. In practice, this places the compound in experiments that measure checkpoint activation, DNA repair, and genome-stability control and chromatin-state control, histone modification, and transcriptional regulation in aging, cancer, and dna damage / repair models.

By inhibiting Sirtuins, NRD167 can be used to examine checkpoint activation, DNA repair, and genome-stability control and chromatin-state control, histone modification, and transcriptional regulation. The epigenetic regulator annotation adds relevance to chromatin, epigenetic, and gene-expression profiling, together with downstream-response mapping in the same experimental setting. In aging, cancer, and dna damage / repair models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.

Research Applications

  • Target-focused assays involving Sirtuins
  • Pathway perturbation studies connected to DNA Damage Response and Epigenetic Regulation
  • Concentration-response inhibition and target-dependence studies
  • Chromatin, epigenetic, and gene-expression profiling

Overall, NRD167 is appropriate when a defined chemical perturbant is needed to connect Sirtuins with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in aging, cancer, and dna damage / repair models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.

Targets:
Sirtuins
Target Class:
Epigenetic Regulator
Pathways:
DNA Damage Response • Epigenetic Regulation
Research Area:
Aging • Cancer • DNA Damage / Repair • Epigenetics
CAS No.:
2166487-23-4
Molecular Weight:
666.83
Formula:
C₃₄H₄₆N₆O₆S
SMILES:
CCOC(=O)CCNC(=S)NCCCCC(NC(=O)OCC1=CC=CC=C1)C(=O)NC(CC2=C[NH]C3=C2C=CC=C3)C(=O)NC(C)C
Storage Temperature:
-20°C

For Research Use Only. Not intended for diagnostic or therapeutic use.
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