NS 1738

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Selleck Chemicals

S0518-5MG

€311,00 EUR
€311,00 EUR
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NS 1738 is a modulator of AChR used in studies of GPCR Signaling and Neurotransmission. In practice, this places the compound in experiments that measure receptor-driven second-messenger signaling and desensitization dynamics and synaptic signaling, receptor activity, and neuronal excitability in neuroscience models.

By modulating AChR, NS 1738 can be used to examine receptor-driven second-messenger signaling and desensitization dynamics and synaptic signaling, receptor activity, and neuronal excitability. This context is compatible with ligand-response, cAMP, calcium-flux, and receptor-pharmacology assays and electrophysiology, neurotransmission, and receptor-response assays, as well as transcriptional, biochemical, or phenotypic comparisons linked to the annotated pathway state. In neuroscience models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.

Research Applications

  • Target-focused assays involving AChR
  • Pathway perturbation studies connected to GPCR Signaling and Neurotransmission
  • Context-dependent response profiling and mechanism comparison
  • Phenotypic profiling in neuroscience models

Overall, NS 1738 is appropriate when a defined chemical perturbant is needed to connect AChR with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in neuroscience models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.

Targets:
AChR
Target Class:
Other
Pathways:
GPCR Signaling • Neurotransmission
Research Area:
Neuroscience
CAS No.:
501684-93-1
Molecular Weight:
365.13
Formula:
C₁₄H₉Cl₂F₃N₂O₂
SMILES:
C1=CC(=C(C=C1C(F)(F)F)NC(=O)NC2=C(C=CC(=C2)Cl)O)Cl
Storage Temperature:
-20°C

For Research Use Only. Not intended for diagnostic or therapeutic use.
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