NSC 74859 (S3I-201)

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Selleck Chemicals

S1155-5MG

€144,00 EUR
€144,00 EUR
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NSC 74859 (S3I-201) is an inhibitor of STAT used in studies of JAK-STAT Signaling. It is especially relevant when investigators need a named chemical input and interpretable readouts connected to cytokine-responsive transcriptional signaling and immune regulation in cancer, cell signaling, and immunology models.

By inhibiting STAT, NSC 74859 (S3I-201) can be used to examine cytokine-responsive transcriptional signaling and immune regulation. The signaling pathway modulator annotation adds relevance to pathway-reporter and mechanistic-phenotyping studies, together with downstream-response mapping in the same experimental setting. In cancer, cell signaling, and immunology models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.

Research Applications

  • Target-focused assays involving STAT
  • Pathway perturbation studies connected to JAK-STAT Signaling
  • Concentration-response inhibition and target-dependence studies
  • Pathway-reporter and mechanistic-phenotyping studies

Overall, NSC 74859 (S3I-201) is appropriate when a defined chemical perturbant is needed to connect STAT with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in cancer, cell signaling, and immunology models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.

Targets:
STAT
Target Class:
Signaling Pathway Modulator
Pathways:
JAK-STAT Signaling
Research Area:
Cancer • Cell Signaling • Immunology
CAS No.:
501919-59-1
Molecular Weight:
365.36
Formula:
C₁₆H₁₅NO₇S
SMILES:
CC1=CC=C(C=C1)S(=O)(=O)OCC(=O)NC2=CC(=C(C=C2)C(=O)O)O
Storage Temperature:
-20°C

For Research Use Only. Not intended for diagnostic or therapeutic use.
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