NSC228155

NSC228155 is an activator of EGFR used in studies of PI3K-Akt-mTOR Signaling and MAPK / ERK Signaling. It is especially relevant in angiogenesis, cancer, and cell signaling models, where defined compound exposure can be linked to growth-factor signaling, survival control, and nutrient-sensing outputs and mitogenic kinase cascades, proliferation control, and differentiation-linked signaling.

By activating EGFR, NSC228155 can be used to examine growth-factor signaling, survival control, and nutrient-sensing outputs and mitogenic kinase cascades, proliferation control, and differentiation-linked signaling. The kinase annotation adds relevance to biochemical kinase assays, phospho-signaling studies, and selectivity profiling, together with downstream-response mapping in the same experimental setting. In angiogenesis, cancer, and cell signaling models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.

Research Applications

• Target-focused assays involving EGFR
• Pathway perturbation studies connected to PI3K-Akt-mTOR Signaling and MAPK / ERK Signaling
• Gain-of-function pathway-activation studies
• Biochemical kinase assays, phospho-signaling studies, and selectivity profiling

Overall, NSC228155 is appropriate when a defined chemical perturbant is needed to connect EGFR with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in angiogenesis, cancer, and cell signaling models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.