Nucleoporin-85 (Nup85 or PCNT1) Antibody - FFPE Validated

Scientific Overview

When you need to assess Nucleoporin-85 with attention to cellular organization, this antibody provides a focused option. Nucleoporin-85 is a microtubule-organizing element often evaluated in cell-cycle and cilia studies. Its behavior can reflect changes in differentiation state, stress, or remodeling of cellular architecture.

In some datasets and protocols, it is referenced by the gene symbol PCNT1.

Research Relevance

Because cilia length and assembly can vary, experimental design often benefits from standardized culture timing. Because regulation can be multi-layered, combining abundance and localization information can sharpen conclusions.

When cell-state transitions occur, this target may change alongside partners in the same compartment or pathway neighborhood.

When building a narrative around the target, it helps to track:

• signal enrichment at basal bodies versus cytoplasm
• co-occurrence with intraflagellar transport markers
• changes in cilia incidence or apparent length in perturbation studies

Application-Specific Context

In sectioned tissue workflows, interpretation often depends on morphology; this format supports that style of readout. Think about how preparation affects epitope accessibility, and interpret patterns alongside morphology and compartment markers as needed.

When interpreting Nucleoporin-85, consider whether changes track with compartment identity, cell density, or perturbation timing; these factors can influence apparent signal without implying a direct causal link.

For challenging targets, pairing Nucleoporin-85 measurements with a second marker can clarify whether differences arise from regulation, redistribution, or shifts in cell composition within the sample.

Use the fixed-section variant when your project demands Nucleoporin-85 readouts that respect preparation constraints.