OLR1/LOX1 Antibody

About the Target

OLR1/LOX1 (lectin-like oxidized LDL receptor-1), encoded by the OLR1 gene on chromosome 12p12-p13, is a type II transmembrane glycoprotein of the C-type lectin family that functions as the primary endothelial receptor for oxidized low-density lipoprotein (oxLDL). Structurally, LOX-1 consists of a short N-terminal cytoplasmic tail, a single transmembrane domain, a neck region, and a C-terminal lectin-like domain responsible for ligand binding. Depending on the literature source, OLR1/LOX1 may also be discussed as OLR1/LOX1 and C-type lectin domain family 8 member A; CLEC8A; hLOX-1; Lectin-like oxidized LDL receptor 1; Lectin-like oxLDL receptor 1; Lectin-type oxidized LDL receptor 1; LOX; LOX 1; LOX-1; LOX1; LOXIN; OLR; OLR 1; OLR-1; OLR1; ox LDL receptor 1; Ox-LDL receptor 1; oxidized low density lipoprotein (lectin-like) receptor 1; oxidized low density lipoprotein rec.

Reported cellular context includes cell membrane, membrane, and secreted, which can matter when signal is compared across treatments or changing cell states. Following OLR1/LOX1 across matched perturbations can help separate abundance effects from shifts in localization, complex assembly, or pathway state.

Research Context

OLR1/LOX1 is commonly interpreted in the context of cardiovascular research, and readouts are often stronger when a study separates expression changes from compartment-level redistribution. When reported signal spans cell membrane, membrane, and secreted, a defined reference condition can make comparisons more interpretable across perturbations, passages, or replicate sets.

Consider these angles when interpreting target-level changes:

• apparent redistribution between cell membrane, membrane, and secreted across matched conditions
• changes linked to vascular, contractile, or hemodynamic cell-state cues
• co-patterning with orthogonal markers and control conditions that clarify pathway state
• time-matched comparisons so changes reflect biology rather than handling or sampling drift

Variant Considerations

If your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior for OLR1/LOX1. This can help when protocols evolve over time and the goal is to compare experiments using a stable reference workflow.

Standardize sampling time, control choice, and downstream analysis thresholds so apparent differences in OLR1/LOX1 reflect biology rather than handling. When interpreting OLR1/LOX1, it is often useful to decide early whether the main question is overall abundance, compartmental enrichment, or context-dependent redistribution.

For multi-run studies, a shared reference condition can keep OLR1/LOX1 trends easier to compare across datasets. That kind of consistency is especially helpful when follow-up work expands to new perturbations, model systems, or longitudinal collections.