P-glycoprotein (MDR1 or ABCB1 or CD243) Antibody - FFPE Validated

Biological Background

To connect mechanism with measurement, this antibody lets you examine P-glycoprotein (MDR1) in pathway-driven studies. P-glycoprotein is a contact-site protein that shapes barrier properties and signaling at the cell surface. Many projects interpret this target alongside interacting partners, upstream cues, and downstream readouts.

In some datasets and protocols, it is referenced by the gene symbol MDR1.

Use in the Laboratory

Shifts in junction organization can accompany migration, tissue morphogenesis, and altered mechanical tension. Considering complex membership and compartment shifts can clarify whether changes reflect signaling or redistribution. Blood-brain barrier models often monitor junction regulation alongside permeability-focused measurements.

Depending on the model, researchers may ask whether signal shifts reflect altered abundance, compartment changes, or remodeling of associated complexes.

To keep datasets interpretable, labs often document:

• co-localization patterns with cytoskeletal elements
• subcellular redistribution at contact sites versus cytoplasm
• changes in complex assembly with scaffold or adaptor proteins

Version Notes

Because fixation can mask epitopes, fixed-section oriented formats aim to maintain recognition after standard deparaffinization and retrieval steps. If your study compares multiple conditions, keep acquisition and processing settings stable to avoid confounding.

For challenging targets, pairing P-glycoprotein measurements with a second marker can clarify whether differences arise from regulation, redistribution, or shifts in cell composition within the sample.

The fixed-section option supports mechanistic reading of P-glycoprotein (MDR1) when interactions and context are the focus.