Padnarsertib (KPT-9274, ATG-019)
Selleck Chemicals
SKU:S8444-2MG
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Padnarsertib (KPT-9274, ATG-019) is an inhibitor of PAK4 used in studies of MAPK / ERK Signaling. In practice, this places the compound in experiments that measure mitogenic kinase cascades, proliferation control, and differentiation-linked signaling in cancer, cell signaling, and metabolism models.
By inhibiting PAK4, Padnarsertib (KPT-9274, ATG-019) can be used to examine mitogenic kinase cascades, proliferation control, and differentiation-linked signaling. The kinase annotation adds relevance to biochemical kinase assays, phospho-signaling studies, and selectivity profiling, together with downstream-response mapping in the same experimental setting. In cancer, cell signaling, and metabolism models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.
Research Applications
- Target-focused assays involving PAK4
- Pathway perturbation studies connected to MAPK / ERK Signaling
- Concentration-response inhibition and target-dependence studies
- Biochemical kinase assays, phospho-signaling studies, and selectivity profiling
Overall, Padnarsertib (KPT-9274, ATG-019) is appropriate when a defined chemical perturbant is needed to connect PAK4 with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in cancer, cell signaling, and metabolism models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.
- Targets:
- PAK4
- Target Class:
- Kinase
- Pathways:
- MAPK / ERK Signaling
- Research Area:
- Cancer • Cell Signaling • Metabolism
- CAS No.:
- 1643913-93-2
- Molecular Weight:
- 610.62
- Formula:
- C₃₅H₂₉F₃N₄O₃
- SMILES:
- C1CN(CCC1(F)F)C(=O)C2=CC=C(C=C2)C3=CC(=C4C(=C3)C=C(O4)CNC(=O)C=CC5=CN=C(C=C5)N)C6=CC=C(C=C6)F
- Storage Temperature:
- -20°C
For Research Use Only. Not intended for diagnostic or therapeutic use.
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