PD123319

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Selleck Chemicals

S7098-5MG

€144,00 EUR
€144,00 EUR
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PD123319 is an antagonist of Angiotensin Receptors used in studies of GPCR Signaling. It is especially relevant in cardiovascular models, where defined compound exposure can be linked to receptor-driven second-messenger signaling and desensitization dynamics. Dose-response comparison, orthogonal validation, and secondary assay follow-up can further sharpen mechanistic interpretation.

By blocking Angiotensin Receptors, PD123319 can be used to examine receptor-driven second-messenger signaling and desensitization dynamics. The gpcr annotation adds relevance to GPCR pharmacology, ligand-binding, and signaling assays, together with downstream-response mapping in the same experimental setting. In cardiovascular models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.

Research Applications

  • Target-focused assays involving Angiotensin Receptors
  • Pathway perturbation studies connected to GPCR Signaling
  • Receptor-blockade and ligand-competition studies
  • GPCR pharmacology, ligand-binding, and signaling assays

Overall, PD123319 is appropriate when a defined chemical perturbant is needed to connect Angiotensin Receptors with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in cardiovascular models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.

Targets:
Angiotensin Receptors
Target Class:
GPCR
Pathways:
GPCR Signaling
Research Area:
Cardiovascular
CAS No.:
130663-39-7
Molecular Weight:
508.61
Formula:
C₃₁H₃₂N₄O₃
SMILES:
CC1=C(C=CC(=C1)CN2C=NC3=C2CC(N(C3)C(=O)C(C4=CC=CC=C4)C5=CC=CC=C5)C(=O)O)N(C)C
Storage Temperature:
-20°C

For Research Use Only. Not intended for diagnostic or therapeutic use.
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