PECAM1 (CD31) Antibody - FFPE Validated

Protein Function

Bring PECAM1 into view to explore changes across conditions. PECAM1 is a structural regulator of intercellular boundaries and tissue architecture. Focus on trends across conditions rather than single-point snapshots.

In some datasets and protocols, it is referenced by the gene symbol CD31.

Experimental Applications

In cultured models, junctional readouts can change rapidly after calcium modulation or cytoskeletal perturbation. Pair measurements with orthogonal readouts when interpretation is sensitive to context.

Many workflows benefit from tracking both signal intensity and compartment distribution, especially when the target participates in multi-protein assemblies. Blood-brain barrier models often monitor junction regulation alongside permeability-focused measurements.

Common experimental questions that benefit from target tracking include:

• comparative profiling across cell states or perturbations
• changes in complex assembly with scaffold or adaptor proteins
• subcellular redistribution at contact sites versus cytoplasm
• co-localization patterns with cytoskeletal elements

Workflow Perspective

For paraffin-embedded samples, fixation history and retrieval strategy matter; this option is aligned to those constraints. To keep comparisons consistent, align sample preparation steps and define a clear baseline for each series.

To support downstream analysis, record key context variables (culture timing, stimulation window, and extraction approach) so PECAM1 patterns can be compared across experiments without guesswork.

For challenging targets, pairing PECAM1 measurements with a second marker can clarify whether differences arise from regulation, redistribution, or shifts in cell composition within the sample.

With a clear focus on PECAM1, this fixed-section option fits streamlined studies and fast iteration.