Pentamidine

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Selleck Chemicals

E4864-50MG

€193,00 EUR
€193,00 EUR
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Pentamidine is an antagonist of TLR used in studies of PI3K-Akt-mTOR Signaling and NF-kB Signaling and related signaling programs. It is especially relevant when investigators need a named chemical input and interpretable readouts connected to growth-factor signaling, survival control, and nutrient-sensing outputs and inflammatory transcriptional control and stress-responsive survival signaling in immunology and inflammation models.

By blocking TLR, Pentamidine can be used to examine growth-factor signaling, survival control, and nutrient-sensing outputs and inflammatory transcriptional control and stress-responsive survival signaling. The immunomodulator annotation adds relevance to immune-cell activation, cytokine, and mediator assays, together with downstream-response mapping in the same experimental setting. In immunology and inflammation models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.

Research Applications

  • Target-focused assays involving TLR
  • Pathway perturbation studies connected to PI3K-Akt-mTOR Signaling and NF-kB Signaling and related signaling programs
  • Receptor-blockade and ligand-competition studies
  • Immune-cell activation, cytokine, and mediator assays

Overall, Pentamidine is appropriate when a defined chemical perturbant is needed to connect TLR with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in immunology and inflammation models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.

Targets:
TLR
Target Class:
Immunomodulator
Pathways:
PI3K-Akt-mTOR Signaling • NF-kB Signaling • Immune Signaling
Research Area:
Immunology • Inflammation
CAS No.:
100-33-4
Molecular Weight:
340.42
Formula:
C₁₉H₂₄N₄O₂
SMILES:
N=C(N)c1ccc(OCCCCCOc2ccc(C(=N)N)cc2)cc1
InChIKey:
XDRYMKDFEDOLFX-UHFFFAOYSA-N
PubChem:
4735
Storage Temperature:
-20°C

For Research Use Only. Not intended for diagnostic or therapeutic use.
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