PF-02341066 (Crizotinib)

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Selleck Chemicals

S1068-5MG

€144,00 EUR
€144,00 EUR
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PF-02341066 (Crizotinib) is an inhibitor of c-Met and ALK and related targets used in studies of PI3K-Akt-mTOR Signaling and MAPK / ERK Signaling and related signaling programs. In practice, this places the compound in experiments that measure growth-factor signaling, survival control, and nutrient-sensing outputs and mitogenic kinase cascades, proliferation control, and differentiation-linked signaling in autophagy, cancer, and cell signaling models.

By inhibiting c-Met and ALK and related targets, PF-02341066 (Crizotinib) can be used to examine growth-factor signaling, survival control, and nutrient-sensing outputs and mitogenic kinase cascades, proliferation control, and differentiation-linked signaling. The kinase annotation adds relevance to biochemical kinase assays, phospho-signaling studies, and selectivity profiling, together with downstream-response mapping in the same experimental setting. In autophagy, cancer, and cell signaling models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.

Research Applications

  • Target-focused assays involving c-Met and ALK and related targets
  • Pathway perturbation studies connected to PI3K-Akt-mTOR Signaling and MAPK / ERK Signaling and related signaling programs
  • Concentration-response inhibition and target-dependence studies
  • Biochemical kinase assays, phospho-signaling studies, and selectivity profiling

Overall, PF-02341066 (Crizotinib) is appropriate when a defined chemical perturbant is needed to connect c-Met and ALK and related targets with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in autophagy, cancer, and cell signaling models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.

Targets:
c-Met • ALK • ROS1
Target Class:
Kinase
Pathways:
PI3K-Akt-mTOR Signaling • MAPK / ERK Signaling • Autophagy
Research Area:
Autophagy • Cancer • Cell Signaling
CAS No.:
877399-52-5
Molecular Weight:
450.34
Formula:
C₂₁H₂₂Cl₂FN₅O
SMILES:
CC(C1=C(C=CC(=C1Cl)F)Cl)OC2=C(N=CC(=C2)C3=CN(N=C3)C4CCNCC4)N
InChIKey:
KTEIFNKAUNYNJU-GFCCVEGCSA-N
PubChem:
11626560
Storage Temperature:
-20°C

For Research Use Only. Not intended for diagnostic or therapeutic use.
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