PF-04691502

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Selleck Chemicals

S2743-5MG

€144,00 EUR
€144,00 EUR
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PF-04691502 is an inhibitor of PI3K and MTOR and related targets used in studies of PI3K-Akt-mTOR Signaling and MAPK / ERK Signaling and related signaling programs. In practice, this places the compound in experiments that measure growth-factor signaling, survival control, and nutrient-sensing outputs and mitogenic kinase cascades, proliferation control, and differentiation-linked signaling in apoptosis, autophagy, and cancer models.

By inhibiting PI3K and MTOR and related targets, PF-04691502 can be used to examine growth-factor signaling, survival control, and nutrient-sensing outputs and mitogenic kinase cascades, proliferation control, and differentiation-linked signaling. The kinase annotation adds relevance to biochemical kinase assays, phospho-signaling studies, and selectivity profiling, together with downstream-response mapping in the same experimental setting. In apoptosis, autophagy, and cancer models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.

Research Applications

  • Target-focused assays involving PI3K and MTOR and related targets
  • Pathway perturbation studies connected to PI3K-Akt-mTOR Signaling and MAPK / ERK Signaling and related signaling programs
  • Concentration-response inhibition and target-dependence studies
  • Biochemical kinase assays, phospho-signaling studies, and selectivity profiling

Overall, PF-04691502 is appropriate when a defined chemical perturbant is needed to connect PI3K and MTOR and related targets with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in apoptosis, autophagy, and cancer models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.

Targets:
PI3K • MTOR • PI3K beta • PI3K alpha
Target Class:
Kinase
Pathways:
PI3K-Akt-mTOR Signaling • MAPK / ERK Signaling • Apoptosis
Research Area:
Apoptosis • Autophagy • Cancer • Cell Signaling
CAS No.:
1013101-36-4
Molecular Weight:
425.48
Formula:
C₂₂H₂₇N₅O₄
SMILES:
CC1=C2C=C(C(=O)N(C2=NC(=N1)N)C3CCC(CC3)OCCO)C4=CN=C(C=C4)OC
InChIKey:
XDLYKKIQACFMJG-UHFFFAOYSA-N
PubChem:
25033539
Storage Temperature:
-20°C

For Research Use Only. Not intended for diagnostic or therapeutic use.
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