PF-06409577

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Selleck Chemicals

S8335-10MG

€144,00 EUR
€144,00 EUR
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PF-06409577 is an activator of AMPK used in studies of PI3K-Akt-mTOR Signaling. In practice, this places the compound in experiments that measure growth-factor signaling, survival control, and nutrient-sensing outputs in autophagy, cancer, and cell signaling models.

By activating AMPK, PF-06409577 can be used to examine growth-factor signaling, survival control, and nutrient-sensing outputs. The kinase annotation adds relevance to biochemical kinase assays, phospho-signaling studies, and selectivity profiling, together with downstream-response mapping in the same experimental setting. In autophagy, cancer, and cell signaling models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.

Research Applications

  • Target-focused assays involving AMPK
  • Pathway perturbation studies connected to PI3K-Akt-mTOR Signaling
  • Gain-of-function pathway-activation studies
  • Biochemical kinase assays, phospho-signaling studies, and selectivity profiling

Overall, PF-06409577 is appropriate when a defined chemical perturbant is needed to connect AMPK with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in autophagy, cancer, and cell signaling models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.

Targets:
AMPK
Target Class:
Kinase
Pathways:
PI3K-Akt-mTOR Signaling
Research Area:
Autophagy • Cancer • Cell Signaling • Metabolism
CAS No.:
1467057-23-3
Molecular Weight:
341.79
Formula:
C₁₉H₁₆ClNO₃
SMILES:
C1CC(C1)(C2=CC=C(C=C2)C3=C(C=C4C(=C3)C(=CN4)C(=O)O)Cl)O
Storage Temperature:
-20°C

For Research Use Only. Not intended for diagnostic or therapeutic use.
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The purchase of this product does not grant any license for commercial use, manufacturing, or clinical applications. The user is responsible for ensuring compliance with applicable laws and third-party rights.