PF-431396

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Selleck Chemicals

S7644-10MG

€144,00 EUR
€144,00 EUR
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PF-431396 is an inhibitor of FAK used in studies of MAPK / ERK Signaling. It is especially relevant in angiogenesis, cancer, and cell signaling models, where defined compound exposure can be linked to mitogenic kinase cascades, proliferation control, and differentiation-linked signaling.

By inhibiting FAK, PF-431396 can be used to examine mitogenic kinase cascades, proliferation control, and differentiation-linked signaling. The kinase annotation adds relevance to biochemical kinase assays, phospho-signaling studies, and selectivity profiling, together with downstream-response mapping in the same experimental setting. In angiogenesis, cancer, and cell signaling models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.

Research Applications

  • Target-focused assays involving FAK
  • Pathway perturbation studies connected to MAPK / ERK Signaling
  • Concentration-response inhibition and target-dependence studies
  • Biochemical kinase assays, phospho-signaling studies, and selectivity profiling

Overall, PF-431396 is appropriate when a defined chemical perturbant is needed to connect FAK with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in angiogenesis, cancer, and cell signaling models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.

Targets:
FAK
Target Class:
Kinase
Pathways:
MAPK / ERK Signaling
Research Area:
Angiogenesis • Cancer • Cell Signaling
CAS No.:
717906-29-1
Molecular Weight:
506.5
Formula:
C₂₂H₂₁F₃N₆O₃S
SMILES:
CN(C1=CC=CC=C1CNC2=NC(=NC=C2C(F)(F)F)NC3=CC4=C(C=C3)NC(=O)C4)S(=O)(=O)C
Storage Temperature:
-20°C

For Research Use Only. Not intended for diagnostic or therapeutic use.
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