PI-103

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Selleck Chemicals

S1038-5MG

€144,00 EUR
€144,00 EUR
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PI-103 is an inhibitor of PI3K and MTOR used in studies of PI3K-Akt-mTOR Signaling and DNA Damage Response and related signaling programs. It is especially relevant in apoptosis, autophagy, and cancer models, where defined compound exposure can be linked to growth-factor signaling, survival control, and nutrient-sensing outputs and checkpoint activation, DNA repair, and genome-stability control.

By inhibiting PI3K and MTOR, PI-103 can be used to examine growth-factor signaling, survival control, and nutrient-sensing outputs and checkpoint activation, DNA repair, and genome-stability control. The kinase annotation adds relevance to biochemical kinase assays, phospho-signaling studies, and selectivity profiling, together with downstream-response mapping in the same experimental setting. In apoptosis, autophagy, and cancer models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.

Research Applications

  • Target-focused assays involving PI3K and MTOR
  • Pathway perturbation studies connected to PI3K-Akt-mTOR Signaling and DNA Damage Response and related signaling programs
  • Concentration-response inhibition and target-dependence studies
  • Biochemical kinase assays, phospho-signaling studies, and selectivity profiling

Overall, PI-103 is appropriate when a defined chemical perturbant is needed to connect PI3K and MTOR with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in apoptosis, autophagy, and cancer models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.

Targets:
PI3K • MTOR
Target Class:
Kinase
Pathways:
PI3K-Akt-mTOR Signaling • DNA Damage Response • Apoptosis
Research Area:
Apoptosis • Autophagy • Cancer • Cell Signaling
CAS No.:
371935-74-9
Molecular Weight:
348.36
Formula:
C₁₉H₁₆N₄O₃
SMILES:
C1COCCN1C2=NC(=NC3=C2OC4=C3C=CC=N4)C5=CC(=CC=C5)O
Storage Temperature:
-20°C

For Research Use Only. Not intended for diagnostic or therapeutic use.
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The purchase of this product does not grant any license for commercial use, manufacturing, or clinical applications. The user is responsible for ensuring compliance with applicable laws and third-party rights.