Podocalyxin (PODXL or gp135) Antibody - FFPE Validated

Scientific Overview

Bring Podocalyxin (PODXL) into view to assess changes across conditions. Podocalyxin is a contact-site protein that shapes barrier properties and signaling at the cell surface. Look for shifts in distribution that track with phenotype changes.

In some datasets and protocols, it is referenced by the gene symbol PODXL.

Research Relevance

Shifts in junction organization can accompany migration, tissue morphogenesis, and altered mechanical tension. Pair measurements with orthogonal readouts when interpretation is sensitive to context.

When cell-state transitions occur, this target may change alongside partners in the same compartment or pathway neighborhood. Podocyte biology studies may assess this target when examining slit-diaphragm organization and cytoskeletal coupling.

When building a narrative around the target, it helps to track:

• comparative profiling across cell states or perturbations
• co-localization patterns with cytoskeletal elements
• subcellular redistribution at contact sites versus cytoplasm
• changes in complex assembly with scaffold or adaptor proteins

Application-Specific Context

This fixed-section oriented version is intended for paraffin-embedded tissue, where crosslinking and retrieval steps can shape epitope accessibility. Think about how preparation affects epitope accessibility, and interpret patterns alongside morphology and compartment markers as needed.

When interpreting Podocalyxin, consider whether changes track with compartment identity, cell density, or perturbation timing; these factors can influence apparent signal without implying a direct causal link.

Select the fixed-section version to keep Podocalyxin (PODXL) interpretation aligned with your workflow goals.