PR-171 (Carfilzomib)
Selleck Chemicals
SKU:S2853-5MG
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PR-171 (Carfilzomib) is an inhibitor of Proteasome used in studies of Apoptosis and Autophagy and related signaling programs. In practice, this places the compound in experiments that measure caspase-associated cell-death signaling and survival decisions and autophagic flux, lysosomal turnover, and stress adaptation in apoptosis, autophagy, and cancer models.
By inhibiting Proteasome, PR-171 (Carfilzomib) can be used to examine caspase-associated cell-death signaling and survival decisions and autophagic flux, lysosomal turnover, and stress adaptation. The protease annotation adds relevance to protease-activity, cleavage, and substrate-processing assays, together with downstream-response mapping in the same experimental setting. In apoptosis, autophagy, and cancer models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.
Research Applications
- Target-focused assays involving Proteasome
- Pathway perturbation studies connected to Apoptosis and Autophagy and related signaling programs
- Concentration-response inhibition and target-dependence studies
- Protease-activity, cleavage, and substrate-processing assays
Overall, PR-171 (Carfilzomib) is appropriate when a defined chemical perturbant is needed to connect Proteasome with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in apoptosis, autophagy, and cancer models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.
- Targets:
- Proteasome
- Target Class:
- Protease
- Pathways:
- Apoptosis • Autophagy • Protein Degradation / Proteasome
- Research Area:
- Apoptosis • Autophagy • Cancer • Protein Homeostasis
- CAS No.:
- 868540-17-4
- Molecular Weight:
- 719.91
- Formula:
- C₄₀H₅₇N₅O₇
- SMILES:
- CC(C)CC(C(=O)C1(CO1)C)NC(=O)C(CC2=CC=CC=C2)NC(=O)C(CC(C)C)NC(=O)C(CCC3=CC=CC=C3)NC(=O)CN4CCOCC4
- InChIKey:
- BLMPQMFVWMYDKT-NZTKNTHTSA-N
- PubChem:
- 11556711
- Storage Temperature:
- -20°C
For Research Use Only. Not intended for diagnostic or therapeutic use.
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