PX-478 Dihydrochloride
Selleck Chemicals
SKU:S7612-5X1MG
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PX-478 Dihydrochloride is an inhibitor of HIF used in studies of Apoptosis. It is especially relevant in angiogenesis, apoptosis, and cancer models, where defined compound exposure can be linked to caspase-associated cell-death signaling and survival decisions.
By inhibiting HIF, PX-478 Dihydrochloride can be used to examine caspase-associated cell-death signaling and survival decisions. The signaling pathway modulator annotation adds relevance to pathway-reporter and mechanistic-phenotyping studies, together with downstream-response mapping in the same experimental setting. In angiogenesis, apoptosis, and cancer models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.
Research Applications
- Target-focused assays involving HIF
- Pathway perturbation studies connected to Apoptosis
- Concentration-response inhibition and target-dependence studies
- Pathway-reporter and mechanistic-phenotyping studies
Overall, PX-478 Dihydrochloride is appropriate when a defined chemical perturbant is needed to connect HIF with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in angiogenesis, apoptosis, and cancer models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.
- Targets:
- HIF
- Target Class:
- Signaling Pathway Modulator
- Pathways:
- Apoptosis
- Research Area:
- Angiogenesis • Apoptosis • Cancer • Cell Signaling
- CAS No.:
- 685898-44-6
- Molecular Weight:
- 394.12
- Formula:
- C₁₃H₂₀Cl₄N₂O₃
- SMILES:
- C1=CC(=CC=C1CC(C(=O)O)N)[N+](CCCl)(CCCl)[O-].Cl.Cl
- InChIKey:
- GIGCDIVNDFQKRA-UHFFFAOYSA-N
- PubChem:
- 11234794
- Storage Temperature:
- -20°C
For Research Use Only. Not intended for diagnostic or therapeutic use.
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