(R)- (-)-Gossypol (AT-101)acetic acid

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Selleck Chemicals

S2812-10MG

€144,00 EUR
€144,00 EUR
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(R)- (-)-Gossypol (AT-101)acetic acid is an inhibitor of BCL-2 used in studies of Apoptosis and Autophagy. It is especially relevant in apoptosis, autophagy, and cancer models, where defined compound exposure can be linked to caspase-associated cell-death signaling and survival decisions and autophagic flux, lysosomal turnover, and stress adaptation.

By inhibiting BCL-2, (R)- (-)-Gossypol (AT-101)acetic acid can be used to examine caspase-associated cell-death signaling and survival decisions and autophagic flux, lysosomal turnover, and stress adaptation. This context is compatible with apoptosis, viability, and caspase-readout assays and autophagy-flux, lysosome, and cargo-clearance assays, as well as transcriptional, biochemical, or phenotypic comparisons linked to the annotated pathway state. In apoptosis, autophagy, and cancer models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.

Research Applications

  • Target-focused assays involving BCL-2
  • Pathway perturbation studies connected to Apoptosis and Autophagy
  • Concentration-response inhibition and target-dependence studies
  • Phenotypic profiling in apoptosis, autophagy, and cancer models

Overall, (R)- (-)-Gossypol (AT-101)acetic acid is appropriate when a defined chemical perturbant is needed to connect BCL-2 with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in apoptosis, autophagy, and cancer models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.

Targets:
BCL-2
Target Class:
Other
Pathways:
Apoptosis • Autophagy
Research Area:
Apoptosis • Autophagy • Cancer
CAS No.:
866541-93-7
Molecular Weight:
578.61
Formula:
C₃₀H₃₀O₈·C₂H₄O₂
SMILES:
CC1=CC2=C(C(=C(C(=C2C(C)C)O)O)C=O)C(=C1C3=C(C4=C(C=C3C)C(=C(C(=C4C=O)O)O)C(C)C)O)O.CC(=O)O
Storage Temperature:
-20°C

For Research Use Only. Not intended for diagnostic or therapeutic use.
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