Rebastinib (DCC-2036)

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Selleck Chemicals

S2634-10MG

€314,00 EUR
€314,00 EUR
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Rebastinib (DCC-2036) is an inhibitor of FLT3 and c-Kit and related targets used in studies of MAPK / ERK Signaling and JAK-STAT Signaling. It is especially relevant in angiogenesis, cancer, and cell signaling models, where defined compound exposure can be linked to mitogenic kinase cascades, proliferation control, and differentiation-linked signaling and cytokine-responsive transcriptional signaling and immune regulation.

By inhibiting FLT3 and c-Kit and related targets, Rebastinib (DCC-2036) can be used to examine mitogenic kinase cascades, proliferation control, and differentiation-linked signaling and cytokine-responsive transcriptional signaling and immune regulation. The kinase annotation adds relevance to biochemical kinase assays, phospho-signaling studies, and selectivity profiling, together with downstream-response mapping in the same experimental setting. In angiogenesis, cancer, and cell signaling models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.

Research Applications

  • Target-focused assays involving FLT3 and c-Kit and related targets
  • Pathway perturbation studies connected to MAPK / ERK Signaling and JAK-STAT Signaling
  • Concentration-response inhibition and target-dependence studies
  • Biochemical kinase assays, phospho-signaling studies, and selectivity profiling

Overall, Rebastinib (DCC-2036) is appropriate when a defined chemical perturbant is needed to connect FLT3 and c-Kit and related targets with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in angiogenesis, cancer, and cell signaling models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.

Targets:
FLT3 • c-Kit • VEGFR2
Target Class:
Kinase
Pathways:
MAPK / ERK Signaling • JAK-STAT Signaling
Research Area:
Angiogenesis • Cancer • Cell Signaling
CAS No.:
1020172-07-9
Molecular Weight:
553.59
Formula:
C₃₀H₂₈FN₇O₃
SMILES:
CC(C)(C)C1=NN(C(=C1)NC(=O)NC2=C(C=C(C=C2)OC3=CC(=NC=C3)C(=O)NC)F)C4=CC5=C(C=C4)N=CC=C5
InChIKey:
WVXNSAVVKYZVOE-UHFFFAOYSA-N
PubChem:
25066467
Storage Temperature:
-20°C

For Research Use Only. Not intended for diagnostic or therapeutic use.
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