RO8994

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Selleck Chemicals

S0167-5MG

€301,00 EUR
€301,00 EUR
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RO8994 is an inhibitor of MDM2 and MDMX used in studies of Apoptosis. In practice, this places the compound in experiments that measure caspase-associated cell-death signaling and survival decisions in apoptosis, cancer, and cell cycle models.

By inhibiting MDM2 and MDMX, RO8994 can be used to examine caspase-associated cell-death signaling and survival decisions. This context is compatible with apoptosis, viability, and caspase-readout assays, as well as transcriptional, biochemical, or phenotypic comparisons linked to the annotated pathway state. In apoptosis, cancer, and cell cycle models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.

Research Applications

  • Target-focused assays involving MDM2 and MDMX
  • Pathway perturbation studies connected to Apoptosis
  • Concentration-response inhibition and target-dependence studies
  • Phenotypic profiling in apoptosis, cancer, and cell cycle models

Overall, RO8994 is appropriate when a defined chemical perturbant is needed to connect MDM2 and MDMX with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in apoptosis, cancer, and cell cycle models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.

Targets:
MDM2 • MDMX
Target Class:
Other
Pathways:
Apoptosis
Research Area:
Apoptosis • Cancer • Cell Cycle
CAS No.:
1309684-94-3
Molecular Weight:
613.51
Formula:
C₃₁H₃₁Cl₂FN₄O₄
SMILES:
CC(C)(C)CC1C2(C(C(N1)C(=O)NC3=C(C=C(C=C3)C(=O)N)OC)C4=C(C(=CC=C4)Cl)F)C5=C(C=C(C=C5)Cl)NC2=O
Storage Temperature:
-20°C

For Research Use Only. Not intended for diagnostic or therapeutic use.
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The purchase of this product does not grant any license for commercial use, manufacturing, or clinical applications. The user is responsible for ensuring compliance with applicable laws and third-party rights.