Ruxolitinib (INCB18424)Phosphate

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Selleck Chemicals

S5243-25MG

€144,00 EUR
€144,00 EUR
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Ruxolitinib (INCB18424)Phosphate is an inhibitor of JAK1 and JAK2 used in studies of JAK-STAT Signaling and Apoptosis and related signaling programs. In practice, this places the compound in experiments that measure cytokine-responsive transcriptional signaling and immune regulation and caspase-associated cell-death signaling and survival decisions in apoptosis, autophagy, and cancer models.

By inhibiting JAK1 and JAK2, Ruxolitinib (INCB18424)Phosphate can be used to examine cytokine-responsive transcriptional signaling and immune regulation and caspase-associated cell-death signaling and survival decisions. The kinase annotation adds relevance to biochemical kinase assays, phospho-signaling studies, and selectivity profiling, together with downstream-response mapping in the same experimental setting. In apoptosis, autophagy, and cancer models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.

Research Applications

  • Target-focused assays involving JAK1 and JAK2
  • Pathway perturbation studies connected to JAK-STAT Signaling and Apoptosis and related signaling programs
  • Concentration-response inhibition and target-dependence studies
  • Biochemical kinase assays, phospho-signaling studies, and selectivity profiling

Overall, Ruxolitinib (INCB18424)Phosphate is appropriate when a defined chemical perturbant is needed to connect JAK1 and JAK2 with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in apoptosis, autophagy, and cancer models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.

Targets:
JAK1 • JAK2
Target Class:
Kinase
Pathways:
JAK-STAT Signaling • Apoptosis • Autophagy
Research Area:
Apoptosis • Autophagy • Cancer • Cell Signaling
CAS No.:
1092939-17-7
Molecular Weight:
404.36
Formula:
C₁₇H₁₈N₆·H₃O₄P
SMILES:
C1CCC(C1)C(CC#N)N2C=C(C=N2)C3=C4C=CNC4=NC=N3.OP(=O)(O)O
Storage Temperature:
-20°C

For Research Use Only. Not intended for diagnostic or therapeutic use.
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