Sacubitril/valsartan (LCZ696)

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Selleck Chemicals

S7678-5MG

€173,00 EUR
€173,00 EUR
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Sacubitril/valsartan (LCZ696) is an inhibitor of Angiotensin Receptors used in studies of GPCR Signaling. It is especially relevant in cardiovascular models, where defined compound exposure can be linked to receptor-driven second-messenger signaling and desensitization dynamics.

By inhibiting Angiotensin Receptors, Sacubitril/valsartan (LCZ696) can be used to examine receptor-driven second-messenger signaling and desensitization dynamics. The gpcr annotation adds relevance to GPCR pharmacology, ligand-binding, and signaling assays, together with downstream-response mapping in the same experimental setting. In cardiovascular models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.

Research Applications

  • Target-focused assays involving Angiotensin Receptors
  • Pathway perturbation studies connected to GPCR Signaling
  • Concentration-response inhibition and target-dependence studies
  • GPCR pharmacology, ligand-binding, and signaling assays

Overall, Sacubitril/valsartan (LCZ696) is appropriate when a defined chemical perturbant is needed to connect Angiotensin Receptors with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in cardiovascular models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.

Targets:
Angiotensin Receptors
Target Class:
GPCR
Pathways:
GPCR Signaling
Research Area:
Cardiovascular
CAS No.:
936623-90-4
Molecular Weight:
915.98
Formula:
C₂₄H₂₉N₅O₃·C₂₄H₂₉NO₅·5/2H₂O·3Na
SMILES:
[Na+].[Na+].[Na+].CCCCC(=O)N(CC1=CC=C(C=C1)C2=CC=CC=C2C3=NN=N[NH]3)C(C(C)C)C(O)=O.CCOC(=O)C(C)CC(CC4=CC=C(C=C4)C5=CC=CC=C5)NC(=O)CCC(O)=O
InChIKey:
OLCIHJOAEZHLPP-UHFFFAOYSA-N
PubChem:
9811834
Storage Temperature:
-20°C

For Research Use Only. Not intended for diagnostic or therapeutic use.
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