SGI-1027

1 1

Selleck Chemicals

S7276-10MG

€144,00 EUR
€144,00 EUR
Sale Sold out
Taxes included. Shipping calculated at checkout.
Size
View full details

SGI-1027 is an inhibitor of DNA Methyltransferases and Transferases used in studies of Apoptosis and Epigenetic Regulation and related signaling programs. It is especially relevant in apoptosis, cancer, and epigenetics models, where defined compound exposure can be linked to caspase-associated cell-death signaling and survival decisions and chromatin-state control, histone modification, and transcriptional regulation.

By inhibiting DNA Methyltransferases and Transferases, SGI-1027 can be used to examine caspase-associated cell-death signaling and survival decisions and chromatin-state control, histone modification, and transcriptional regulation. The epigenetic regulator annotation adds relevance to chromatin, epigenetic, and gene-expression profiling, together with downstream-response mapping in the same experimental setting. In apoptosis, cancer, and epigenetics models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.

Research Applications

  • Target-focused assays involving DNA Methyltransferases and Transferases
  • Pathway perturbation studies connected to Apoptosis and Epigenetic Regulation and related signaling programs
  • Concentration-response inhibition and target-dependence studies
  • Chromatin, epigenetic, and gene-expression profiling

Overall, SGI-1027 is appropriate when a defined chemical perturbant is needed to connect DNA Methyltransferases and Transferases with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in apoptosis, cancer, and epigenetics models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.

Targets:
DNA Methyltransferases • Transferases
Target Class:
Epigenetic Regulator
Pathways:
Apoptosis • Epigenetic Regulation • Metabolic Signaling
Research Area:
Apoptosis • Cancer • Epigenetics • Metabolism
CAS No.:
1020149-73-8
Molecular Weight:
461.52
Formula:
C₂₇H₂₃N₇O
SMILES:
CC1=CC(=NC(=N1)N)NC2=CC=C(C=C2)NC(=O)C3=CC=C(C=C3)NC4=CC=NC5=CC=CC=C54
Storage Temperature:
-20°C

For Research Use Only. Not intended for diagnostic or therapeutic use.
Products may be subject to intellectual property rights.

The purchase of this product does not grant any license for commercial use, manufacturing, or clinical applications. The user is responsible for ensuring compliance with applicable laws and third-party rights.