SKI II

1 1

Selleck Chemicals

S7176-25MG

€144,00 EUR
€144,00 EUR
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SKI II is an inhibitor of Sphingosine Kinases used in studies of PI3K-Akt-mTOR Signaling and Metabolic Signaling. It is especially relevant when investigators need a named chemical input and interpretable readouts connected to growth-factor signaling, survival control, and nutrient-sensing outputs and metabolic regulation, energy sensing, and enzyme-linked homeostasis in cancer, cell signaling, and immunology models.

By inhibiting Sphingosine Kinases, SKI II can be used to examine growth-factor signaling, survival control, and nutrient-sensing outputs and metabolic regulation, energy sensing, and enzyme-linked homeostasis. The kinase annotation adds relevance to biochemical kinase assays, phospho-signaling studies, and selectivity profiling, together with downstream-response mapping in the same experimental setting. In cancer, cell signaling, and immunology models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.

Research Applications

  • Target-focused assays involving Sphingosine Kinases
  • Pathway perturbation studies connected to PI3K-Akt-mTOR Signaling and Metabolic Signaling
  • Concentration-response inhibition and target-dependence studies
  • Biochemical kinase assays, phospho-signaling studies, and selectivity profiling

Overall, SKI II is appropriate when a defined chemical perturbant is needed to connect Sphingosine Kinases with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in cancer, cell signaling, and immunology models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.

Targets:
Sphingosine Kinases
Target Class:
Kinase
Pathways:
PI3K-Akt-mTOR Signaling • Metabolic Signaling
Research Area:
Cancer • Cell Signaling • Immunology • Inflammation
CAS No.:
312636-16-1
Molecular Weight:
302.78
Formula:
C₁₅H₁₁ClN₂OS
SMILES:
C1=CC(=CC=C1C2=CSC(=N2)NC3=CC=C(C=C3)O)Cl
Storage Temperature:
-20°C

For Research Use Only. Not intended for diagnostic or therapeutic use.
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