Sonidegib (NVP-LDE225, Erismodegib)
Selleck Chemicals
SKU:S2151-5MG
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Sonidegib (NVP-LDE225, Erismodegib) is an antagonist of Hedgehog used in studies of Wnt Signaling and Hedgehog Signaling. In practice, this places the compound in experiments that measure beta-catenin-dependent transcription and developmental signaling and morphogen-dependent developmental signaling and transcriptional patterning in cancer, developmental biology, and stem cell biology models.
By blocking Hedgehog, Sonidegib (NVP-LDE225, Erismodegib) can be used to examine beta-catenin-dependent transcription and developmental signaling and morphogen-dependent developmental signaling and transcriptional patterning. The signaling pathway modulator annotation adds relevance to pathway-reporter and mechanistic-phenotyping studies, together with downstream-response mapping in the same experimental setting. In cancer, developmental biology, and stem cell biology models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.
Research Applications
- Target-focused assays involving Hedgehog
- Pathway perturbation studies connected to Wnt Signaling and Hedgehog Signaling
- Receptor-blockade and ligand-competition studies
- Pathway-reporter and mechanistic-phenotyping studies
Overall, Sonidegib (NVP-LDE225, Erismodegib) is appropriate when a defined chemical perturbant is needed to connect Hedgehog with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in cancer, developmental biology, and stem cell biology models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.
- Targets:
- Hedgehog
- Target Class:
- Signaling Pathway Modulator
- Pathways:
- Wnt Signaling • Hedgehog Signaling
- Research Area:
- Cancer • Developmental Biology • Stem Cell Biology
- CAS No.:
- 956697-53-3
- Molecular Weight:
- 485.5
- Formula:
- C₂₆H₂₆F₃N₃O₃
- SMILES:
- CC1CN(CC(O1)C)C2=NC=C(C=C2)NC(=O)C3=CC=CC(=C3C)C4=CC=C(C=C4)OC(F)(F)F
- InChIKey:
- VZZJRYRQSPEMTK-UHFFFAOYSA-N
- PubChem:
- 24775005
- Storage Temperature:
- -20°C
For Research Use Only. Not intended for diagnostic or therapeutic use.
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