Sorafenib (BAY 43-9006)

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Selleck Chemicals

S7397-20MG

€144,00 EUR
€144,00 EUR
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Sorafenib (BAY 43-9006) is an inhibitor of RAF and VEGFR and related targets used in studies of MAPK / ERK Signaling and JAK-STAT Signaling and related signaling programs. It is especially relevant when investigators need a named chemical input and interpretable readouts connected to mitogenic kinase cascades, proliferation control, and differentiation-linked signaling and cytokine-responsive transcriptional signaling and immune regulation in angiogenesis, apoptosis, and autophagy models.

By inhibiting RAF and VEGFR and related targets, Sorafenib (BAY 43-9006) can be used to examine mitogenic kinase cascades, proliferation control, and differentiation-linked signaling and cytokine-responsive transcriptional signaling and immune regulation. The kinase annotation adds relevance to biochemical kinase assays, phospho-signaling studies, and selectivity profiling, together with downstream-response mapping in the same experimental setting. In angiogenesis, apoptosis, and autophagy models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.

Research Applications

  • Target-focused assays involving RAF and VEGFR and related targets
  • Pathway perturbation studies connected to MAPK / ERK Signaling and JAK-STAT Signaling and related signaling programs
  • Concentration-response inhibition and target-dependence studies
  • Biochemical kinase assays, phospho-signaling studies, and selectivity profiling

Overall, Sorafenib (BAY 43-9006) is appropriate when a defined chemical perturbant is needed to connect RAF and VEGFR and related targets with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in angiogenesis, apoptosis, and autophagy models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.

Targets:
RAF • VEGFR • BRAF • FLT3
Target Class:
Kinase
Pathways:
MAPK / ERK Signaling • JAK-STAT Signaling • Apoptosis
Research Area:
Angiogenesis • Apoptosis • Autophagy • Cancer
CAS No.:
284461-73-0
Molecular Weight:
464.82
Formula:
C₂₁H₁₆ClF₃N₄O₃
SMILES:
CNC(=O)C1=NC=CC(=C1)OC2=CC=C(C=C2)NC(=O)NC3=CC(=C(C=C3)Cl)C(F)(F)F
InChIKey:
MLDQJTXFUGDVEO-UHFFFAOYSA-N
PubChem:
216239
Storage Temperature:
-20°C

For Research Use Only. Not intended for diagnostic or therapeutic use.
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