SPD304

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Selleck Chemicals

S8431-5MG

€363,00 EUR
€363,00 EUR
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SPD304 is an inhibitor of TNF-alpha used in studies of NF-kB Signaling and Immune Signaling. In practice, this places the compound in experiments that measure inflammatory transcriptional control and stress-responsive survival signaling and cytokine-mediated signaling and inflammatory effector responses in immunology and inflammation models.

By inhibiting TNF-alpha, SPD304 can be used to examine inflammatory transcriptional control and stress-responsive survival signaling and cytokine-mediated signaling and inflammatory effector responses. The immunomodulator annotation adds relevance to immune-cell activation, cytokine, and mediator assays, together with downstream-response mapping in the same experimental setting. In immunology and inflammation models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.

Research Applications

  • Target-focused assays involving TNF-alpha
  • Pathway perturbation studies connected to NF-kB Signaling and Immune Signaling
  • Concentration-response inhibition and target-dependence studies
  • Immune-cell activation, cytokine, and mediator assays

Overall, SPD304 is appropriate when a defined chemical perturbant is needed to connect TNF-alpha with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in immunology and inflammation models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.

Targets:
TNF-alpha
Target Class:
Immunomodulator
Pathways:
NF-kB Signaling • Immune Signaling
Research Area:
Immunology • Inflammation
CAS No.:
869998-49-2
Molecular Weight:
547.61
Formula:
C₃₂H₃₂F₃N₃O₂
SMILES:
CN(CCN(C)CC1=C[N](C2=CC(=CC=C2)C(F)(F)F)C3=CC=CC=C13)CC4=COC5=CC(=C(C)C=C5C4=O)C
Storage Temperature:
-20°C

For Research Use Only. Not intended for diagnostic or therapeutic use.
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The purchase of this product does not grant any license for commercial use, manufacturing, or clinical applications. The user is responsible for ensuring compliance with applicable laws and third-party rights.