SR-3677

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Selleck Chemicals

E2383

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SR-3677 is an inhibitor of ROCK used in studies of kinase signaling. It is especially relevant when investigators need a named chemical input and interpretable readouts connected to phosphorylation signaling, target engagement, and selectivity relationships in cancer, cardiovascular, and cell cycle models.

By inhibiting ROCK, SR-3677 can be used to examine phosphorylation signaling, target engagement, and selectivity relationships. This target class is commonly examined through biochemical kinase assays, phospho-signaling studies, and selectivity profiling, together with downstream-response mapping. In cancer, cardiovascular, and cell cycle models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.

Research Applications

  • Target-focused assays involving ROCK
  • Concentration-response inhibition and target-dependence studies
  • Biochemical kinase assays, phospho-signaling studies, and selectivity profiling
  • Phenotypic profiling in cancer, cardiovascular, and cell cycle models

Overall, SR-3677 is appropriate when a defined chemical perturbant is needed to connect ROCK with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in cancer, cardiovascular, and cell cycle models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.

Targets:
ROCK
Target Class:
Kinase
Research Area:
Cancer • Cardiovascular • Cell Cycle • Cell Signaling
CAS No.:
1072959-67-1
Molecular Weight:
408.45
Storage Temperature:
-20°C

For Research Use Only. Not intended for diagnostic or therapeutic use.
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The purchase of this product does not grant any license for commercial use, manufacturing, or clinical applications. The user is responsible for ensuring compliance with applicable laws and third-party rights.