SRT-1460
Selleck Chemicals
SKU:S6880-5MG
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SRT-1460 is an activator of Sirtuins used in studies of DNA Damage Response and Apoptosis and related signaling programs. In practice, this places the compound in experiments that measure checkpoint activation, DNA repair, and genome-stability control and caspase-associated cell-death signaling and survival decisions in aging, apoptosis, and cancer models.
By activating Sirtuins, SRT-1460 can be used to examine checkpoint activation, DNA repair, and genome-stability control and caspase-associated cell-death signaling and survival decisions. The epigenetic regulator annotation adds relevance to chromatin, epigenetic, and gene-expression profiling, together with downstream-response mapping in the same experimental setting. In aging, apoptosis, and cancer models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.
Research Applications
- Target-focused assays involving Sirtuins
- Pathway perturbation studies connected to DNA Damage Response and Apoptosis and related signaling programs
- Gain-of-function pathway-activation studies
- Chromatin, epigenetic, and gene-expression profiling
Overall, SRT-1460 is appropriate when a defined chemical perturbant is needed to connect Sirtuins with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in aging, apoptosis, and cancer models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.
- Targets:
- Sirtuins
- Target Class:
- Epigenetic Regulator
- Pathways:
- DNA Damage Response • Apoptosis • Epigenetic Regulation
- Research Area:
- Aging • Apoptosis • Cancer • DNA Damage / Repair
- CAS No.:
- 925432-73-1
- Molecular Weight:
- 507.60
- Formula:
- C₂₆H₂₉N₅O₄S
- SMILES:
- COC1=C(OC)C(=CC(=C1)C(=O)NC2=CC=CC=C2C3=C[N]4C(=CSC4=N3)CN5CCNCC5)OC
- Storage Temperature:
- -20°C
For Research Use Only. Not intended for diagnostic or therapeutic use.
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