Stathmin 1 Antibody

About the Target

Stathmin 1, also known as Oncoprotein 18 (OP18), LAP18, or Metablastin, is a cytoplasmic phosphoprotein that functions as a key microtubule destabilizer, playing crucial roles in cell cycle progression, chromosome segregation, proliferation, motility, and survival. Structurally, it contains a conserved Stathmin-like domain with four serine phosphorylation sites (Ser16, Ser25, Ser38, Ser68) at the N-terminal region and a tubulin-binding domain, enabling it to promote microtubule catastrophe or sequester α/β-tubulin heterodimers, thus preventing microtubule polymerization.

Reported cellular context includes cytoplasm, cytoskeleton, and microtubule, which can matter when signal is compared across treatments or changing cell states. Following Stathmin 1 across matched perturbations can help separate abundance effects from shifts in localization, complex assembly, or pathway state.

Research Context

Stathmin 1 is commonly interpreted in the context of stem cell biology research, and readouts are often stronger when a study separates expression changes from compartment-level redistribution. When reported signal spans cytoplasm, cytoskeleton, and microtubule, a defined reference condition can make comparisons more interpretable across perturbations, passages, or replicate sets.

Consider these angles when interpreting target-level changes:

• apparent redistribution between cytoplasm, cytoskeleton, and microtubule across matched conditions
• state transitions between self-renewal, priming, and differentiation
• co-patterning with orthogonal markers and control conditions that clarify pathway state
• time-matched comparisons so changes reflect biology rather than handling or sampling drift

Variant Considerations

If your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior for Stathmin 1. This can help when protocols evolve over time and the goal is to compare experiments using a stable reference workflow.

Standardize sampling time, control choice, and downstream analysis thresholds so apparent differences in Stathmin 1 reflect biology rather than handling. When interpreting Stathmin 1, it is often useful to decide early whether the main question is overall abundance, compartmental enrichment, or context-dependent redistribution.

For multi-run studies, a shared reference condition can keep Stathmin 1 trends easier to compare across datasets. That kind of consistency is especially helpful when follow-up work expands to new perturbations, model systems, or longitudinal collections.