Phospho-Stathmin (Ser38) Antibody

About the Target

Stathmin (STMN1), also known as Oncoprotein 18 (Op18), is a highly conserved 18-kDa cytosolic phosphoprotein that plays a critical role in enhancing mitosis by promoting microtubule dynamics. STMN1 contains four serine phosphorylation sites: Ser16, Ser25, Ser38, and Ser63. Phosphorylation at Ser16 or Ser63 significantly decreases or prevents STMN1's ability to bind to and sequester soluble tubulin. Depending on the literature source, STATHMIN may also be discussed as Phospho-Stathmin (Ser38).

Reported cellular context includes cytoplasm, cytoskeleton, and microtubule, which can matter when signal is compared across treatments or changing cell states. Following STATHMIN across matched perturbations can help separate abundance effects from shifts in localization, complex assembly, or pathway state.

Research Context

STATHMIN is commonly interpreted in the context of cancer, cell cycle, and cell signaling research, and readouts are often stronger when a study separates expression changes from compartment-level redistribution. When reported signal spans cytoplasm, cytoskeleton, and microtubule, a defined reference condition can make comparisons more interpretable across perturbations, passages, or replicate sets.

Consider these angles when interpreting target-level changes:

• apparent redistribution between cytoplasm, cytoskeleton, and microtubule across matched conditions
• changes associated with proliferative state, oncogenic signaling, or treatment response
• cell-cycle linked differences in abundance, timing, or compartmental enrichment
• signal-dependent shifts after ligand, inhibitor, or growth-factor perturbation

Variant Considerations

If your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior for STATHMIN. This can help when protocols evolve over time and the goal is to compare experiments using a stable reference workflow.

Standardize sampling time, control choice, and downstream analysis thresholds so apparent differences in STATHMIN reflect biology rather than handling. When interpreting STATHMIN, it is often useful to decide early whether the main question is overall abundance, compartmental enrichment, or context-dependent redistribution.

For multi-run studies, a shared reference condition can keep STATHMIN trends easier to compare across datasets. That kind of consistency is especially helpful when follow-up work expands to new perturbations, model systems, or longitudinal collections.