Sulfasalazine

1 1

Selleck Chemicals

S1576-500MG

€144,00 EUR
€144,00 EUR
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Sulfasalazine is an inhibitor of NF-kB and TGF-beta / Smad and related targets used in studies of NF-kB Signaling and Immune Signaling and related signaling programs. In practice, this places the compound in experiments that measure inflammatory transcriptional control and stress-responsive survival signaling and cytokine-mediated signaling and inflammatory effector responses in apoptosis, autophagy, and cancer models.

By inhibiting NF-kB and TGF-beta / Smad and related targets, Sulfasalazine can be used to examine inflammatory transcriptional control and stress-responsive survival signaling and cytokine-mediated signaling and inflammatory effector responses. The signaling pathway modulator annotation adds relevance to pathway-reporter and mechanistic-phenotyping studies, together with downstream-response mapping in the same experimental setting. In apoptosis, autophagy, and cancer models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.

Research Applications

  • Target-focused assays involving NF-kB and TGF-beta / Smad and related targets
  • Pathway perturbation studies connected to NF-kB Signaling and Immune Signaling and related signaling programs
  • Concentration-response inhibition and target-dependence studies
  • Pathway-reporter and mechanistic-phenotyping studies

Overall, Sulfasalazine is appropriate when a defined chemical perturbant is needed to connect NF-kB and TGF-beta / Smad and related targets with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in apoptosis, autophagy, and cancer models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.

Targets:
NF-kB • TGF-beta / Smad • COX-2
Target Class:
Signaling Pathway Modulator
Pathways:
NF-kB Signaling • Immune Signaling • TGF-beta / Smad Signaling
Research Area:
Apoptosis • Autophagy • Cancer • Cell Signaling
CAS No.:
599-79-1
Molecular Weight:
398.39
Formula:
C₁₈H₁₄N₄O₅S
SMILES:
C1=CC=NC(=C1)NS(=O)(=O)C2=CC=C(C=C2)N=NC3=CC(=C(C=C3)O)C(=O)O
InChIKey:
NCEXYHBECQHGNR-QZQOTICOSA-N
PubChem:
5359476
Storage Temperature:
-20°C

For Research Use Only. Not intended for diagnostic or therapeutic use.
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