Sunitinib (SU11248)Malate

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Selleck Chemicals

S1042-10MG

€75,00 EUR
€75,00 EUR
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Sunitinib (SU11248)Malate is an inhibitor of VEGFR2 and PDGFR and related targets used in studies of MAPK / ERK Signaling and JAK-STAT Signaling and related signaling programs. It is especially relevant when investigators need a named chemical input and interpretable readouts connected to mitogenic kinase cascades, proliferation control, and differentiation-linked signaling and cytokine-responsive transcriptional signaling and immune regulation in angiogenesis, apoptosis, and cancer models.

By inhibiting VEGFR2 and PDGFR and related targets, Sunitinib (SU11248)Malate can be used to examine mitogenic kinase cascades, proliferation control, and differentiation-linked signaling and cytokine-responsive transcriptional signaling and immune regulation. The kinase annotation adds relevance to biochemical kinase assays, phospho-signaling studies, and selectivity profiling, together with downstream-response mapping in the same experimental setting. In angiogenesis, apoptosis, and cancer models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.

Research Applications

  • Target-focused assays involving VEGFR2 and PDGFR and related targets
  • Pathway perturbation studies connected to MAPK / ERK Signaling and JAK-STAT Signaling and related signaling programs
  • Concentration-response inhibition and target-dependence studies
  • Biochemical kinase assays, phospho-signaling studies, and selectivity profiling

Overall, Sunitinib (SU11248)Malate is appropriate when a defined chemical perturbant is needed to connect VEGFR2 and PDGFR and related targets with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in angiogenesis, apoptosis, and cancer models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.

Targets:
VEGFR2 • PDGFR • FLT3
Target Class:
Kinase
Pathways:
MAPK / ERK Signaling • JAK-STAT Signaling • Apoptosis
Research Area:
Angiogenesis • Apoptosis • Cancer • Cell Signaling
CAS No.:
341031-54-7
Molecular Weight:
532.56
Formula:
C₂₂H₂₇FN₄O₂·C₄H₆O₅
SMILES:
CCN(CC)CCNC(=O)C1=C(NC(=C1C)C=C2C3=C(C=CC(=C3)F)NC2=O)C.C(C(C(=O)O)O)C(=O)O
Storage Temperature:
-20°C

For Research Use Only. Not intended for diagnostic or therapeutic use.
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