TAS-116 (Pimitespib)

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Selleck Chemicals

S7716-5MG

€144,00 EUR
€144,00 EUR
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TAS-116 (Pimitespib) is an inhibitor of HSP90 used in studies of target-focused biology. In practice, this places the compound in experiments that measure annotated target biology and downstream cellular responses in cancer and protein homeostasis models.

By inhibiting HSP90, TAS-116 (Pimitespib) can be used to examine annotated target biology and downstream cellular responses. That positioning is consistent with concentration-response inhibition and target-dependence studies and with follow-up studies that compare concentration-dependent responses across orthogonal assay formats. In cancer and protein homeostasis models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.

Research Applications

  • Target-focused assays involving HSP90
  • Concentration-response inhibition and target-dependence studies
  • Phenotypic profiling in cancer and protein homeostasis models
  • Combination studies with orthogonal perturbagens

Overall, TAS-116 (Pimitespib) is appropriate when a defined chemical perturbant is needed to connect HSP90 with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in cancer and protein homeostasis models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.

Targets:
HSP90
Target Class:
Other
Research Area:
Cancer • Protein Homeostasis
CAS No.:
1260533-36-5
Molecular Weight:
454.53
Formula:
C₂₅H₂₆N₈O
SMILES:
CCC1=C(C=CC(=C1)C(=O)N)N2C3=NC=CC(=C3C(=N2)C(C)C)N4C=C(N=C4)C5=CN(N=C5)C
InChIKey:
NVVPMZUGELHVMH-UHFFFAOYSA-N
PubChem:
67501411
Storage Temperature:
-20°C

For Research Use Only. Not intended for diagnostic or therapeutic use.
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