Tetraspanin-20 (TSPAN20 or Uroplakin-1b or UPK1B or UPK1) Antibody - Western Blot Validated

Scientific Overview

To connect mechanism with measurement, this antibody lets you investigate Tetraspanin-20 (UPK1) in pathway-driven studies. Tetraspanin-20 is an adhesion-related target that can shift with substrate composition and mechanical cues. Many projects interpret this target alongside interacting partners, upstream cues, and downstream readouts.

In some datasets and protocols, it is referenced by the gene symbol UPK1.

Research Relevance

Perturbations that disrupt integrin engagement or actomyosin tension can reshape localization and complex assembly. Considering complex membership and compartment shifts can clarify whether changes reflect signaling or redistribution.

Because cellular networks are interconnected, changes in this target may coincide with shifts in related pathways, trafficking behavior, or structural remodeling.

When building a narrative around the target, it helps to track:

• effects of adhesion inhibitors or matrix composition
• focal adhesion versus diffuse membrane distribution
• remodeling after changes in substrate or mechanical stress

Application-Specific Context

If your primary readout depends on denatured protein presentation, this option can streamline comparison across lanes and conditions. Think about how preparation affects epitope accessibility, and interpret patterns alongside morphology and compartment markers as needed. If signaling is transient, sampling time can be as important as condition.

If your study spans multiple model systems, it can help to define a shared reference condition for Tetraspanin-20 so cross-sample contrasts stay meaningful.

The denaturing-format option supports mechanistic reading of Tetraspanin-20 (UPK1) when interactions and context are the focus.