Thalidomide

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Selleck Chemicals

S1193-200MG

€144,00 EUR
€144,00 EUR
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Thalidomide is a substrate of E3 Ligase and TNF-alpha used in studies of NF-kB Signaling and Immune Signaling and related signaling programs. In practice, this places the compound in experiments that measure inflammatory transcriptional control and stress-responsive survival signaling and cytokine-mediated signaling and inflammatory effector responses in cancer, immunology, and inflammation models.

As a substrate linked to E3 Ligase and TNF-alpha, Thalidomide can be used to examine inflammatory transcriptional control and stress-responsive survival signaling and cytokine-mediated signaling and inflammatory effector responses. The enzyme annotation adds relevance to enzyme-activity assays, substrate-conversion studies, and mechanism profiling, together with downstream-response mapping in the same experimental setting. In cancer, immunology, and inflammation models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.

Research Applications

  • Target-focused assays involving E3 Ligase and TNF-alpha
  • Pathway perturbation studies connected to NF-kB Signaling and Immune Signaling and related signaling programs
  • Kinetic, turnover, and substrate-competition experiments
  • Enzyme-activity assays, substrate-conversion studies, and mechanism profiling

Overall, Thalidomide is appropriate when a defined chemical perturbant is needed to connect E3 Ligase and TNF-alpha with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in cancer, immunology, and inflammation models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.

Targets:
E3 Ligase • TNF-alpha
Target Class:
Enzyme
Pathways:
NF-kB Signaling • Immune Signaling • Protein Degradation / Proteasome
Research Area:
Cancer • Immunology • Inflammation • Protein Homeostasis
CAS No.:
50-35-1
Molecular Weight:
258.23
Formula:
C₁₃H₁₀N₂O₄
SMILES:
C1CC(=O)NC(=O)C1N2C(=O)C3=CC=CC=C3C2=O
InChIKey:
UEJJHQNACJXSKW-UHFFFAOYSA-N
PubChem:
5426
Storage Temperature:
-20°C

For Research Use Only. Not intended for diagnostic or therapeutic use.
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